Status:

COMPLETED

Study Of Sunitinib With Capecitabine In Breast Cancer

Lead Sponsor:

Pfizer

Conditions:

Advanced/Metastatic Breast Cancer

Eligibility:

FEMALE

20+ years

Phase:

PHASE2

Brief Summary

To evaluate efficacy, safety and pharmacokinetics of sunitinib plus Capecitabine in Japanese patients with advanced/metastatic breast cancer.

Eligibility Criteria

Inclusion

  • Histologically- or cytologically-proven diagnosis of breast adenocarcinoma that is not amenable to surgery, radiation, or combined modality therapy with curative intent
  • Measurable disease as per RECIST. Measurable lesions that have been previously irradiated will not be considered target lesions unless increase in size has been observed following completion of radiation therapy.
  • Prior treatment with an anthracycline and a taxane in the neoadjuvant, adjuvant or metastatic disease settings.

Exclusion

  • Histology of inflammatory carcinoma with no other measurable disease. Patients with histology of inflammatory carcinoma are allowed on study if they have measurable disease.
  • Brain metastases, spinal cord compression, or carcinomatous meningitis, or leptomeningeal disease.
  • Prior treatment with 5-fluorouracil (5-FU) and 5-FU derivatives such as Furtulon (5'-DFUR), Futraful/ Sunfural (tegafur), UFT/UFT-E (tegafur/uracil), TS-1 (tegafur/gimeracil/oteracil) or Mifurol (carmofur) in metastatic disease setting

Key Trial Info

Start Date :

April 1 2008

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

May 1 2012

Estimated Enrollment :

63 Patients enrolled

Trial Details

Trial ID

NCT00662025

Start Date

April 1 2008

End Date

May 1 2012

Last Update

May 27 2013

Active Locations (17)

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Page 1 of 5 (17 locations)

1

Pfizer Investigational Site

Anjo, Aichi-ken, Japan

2

Pfizer Investigational Site

Nagoya, Aichi-ken, Japan

3

Pfizer Investigational Site

Okazaki, Aichi-ken, Japan

4

Pfizer Investigational Site

Toyoake, Aichi-ken, Japan