Status:
COMPLETED
Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Conditions:
Critically Ill
Hemodialysis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Daptomycin is an antibiotic that is affective against many strains of antibiotic resistant microorganisms. This antibiotic would be appropriate for use in the intensive care unit (ICU) considering the...
Detailed Description
Daptomycin is a FDA approved antibiotic. This pharmacokinetic trial will monitor daptomycin drug concentrations during continuous hemodialysis. The daptomycin concentration profiles developed from thi...
Eligibility Criteria
Inclusion
- =/\> 18 years of age
- Prescribed Continuous Venovenous Hemodialysis (CVVHD) as determined by the primary physician
- Prescribed daptomycin as determined by the primary physician
- Informed consent granted
Exclusion
- \< 18 years of age
- Allergy to daptomycin
- Patients being primarily treated with daptomycin for diagnosis of osteomyelitis, meningitis, or pneumonia without adequate concomitant use of other more effective antimicrobial agents as daptomycin is not indicated for primary treatment of these types of infections
- Inability to complete 48 hours of Continuous Venovenous Hemodialysis (CVVHD)
- Concurrent use of other extracorporeal therapies such as Extracorporeal Membrane Oxygenation (ECMO) or plasmapheresis and intermittent hemodialysis
- Inability to obtain informed consent
- Pregnant and/or breastfeeding women
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00663403
Start Date
February 1 2007
End Date
April 1 2009
Last Update
December 30 2015
Active Locations (1)
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1
University of Michigan University Hospital
Ann Arbor, Michigan, United States, 48109