Status:
TERMINATED
Thyroid Hormones in Critically Ill Children
Lead Sponsor:
Children's Hospital of Philadelphia
Conditions:
Hypotension
Respiratory Failure
Eligibility:
All Genders
12-18 years
Brief Summary
Thyroid hormones are substances naturally made by the body and are important to many of your body's basic functions such as breathing and brain function. We are investigating whether or not these horm...
Detailed Description
We hypothesize that critically ill children that require vasoactive infusions and/or invasive mechanical ventilation have thyroid hormone alterations. We will measure TSH, tT3, fT3, rT3, tT4, fT4, adn...
Eligibility Criteria
Inclusion
- Informed Consent
- Age of less than 12 months and less than or equal to 18
- Patient must weigh greater than 10 kgs.
- Patients must require vasoactive infusions and/or mechanical ventilation.
- Patients must be enrolled within 24 hours of meeting eligibility.
Exclusion
- Patient with known or presumed pre-existing thyroid disease will be excluded
- Patients who receive thyroid supplementation will be excluded
- Patients with known or presumed hypothalamic and/or pituitary dysfunction that have thyroid hormone concentration abnormalities not related to an acute illness.
- Patients who are intubated for airway protection only.
- Patients intubated for neuromuscular disease
- Pregnant patients.
- Patients receiving amiodarone supplementation
- Patients who received blood product transfusions equaling more than 1/2 of their blood volume.
Key Trial Info
Start Date :
October 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00664079
Start Date
October 1 2005
End Date
December 1 2008
Last Update
March 12 2015
Active Locations (1)
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1
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104