Status:
UNKNOWN
Relation of Catechol-O-methyltransferase (COMT) Genotype and Response to Cognitive Remediation Schizophrenia
Lead Sponsor:
Manhattan Psychiatric Center
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Albert Einstein College of Medicine
Conditions:
Chronic Schizophrenia
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
This project will explore the relationship between catechol-O-methyltransferase (COMT) Val158/108Met genotype and response to a 12-week computerized neurocognitive rehabilitation (CRT) given to chroni...
Detailed Description
Cognitive deficits play a crucial role in both the pathogenesis and prognosis of schizophrenia. The COMT gene is functionally expressed in neural systems considered important in a range of healthy bra...
Eligibility Criteria
Inclusion
- Participation in the active arm of the neurocognitive remediation program
- Age 18 - 55
- Inpatients
- DSM-IV diagnosis of schizophrenia (all subtypes) with illness duration \>5 years
- Auditory and visual acuity adequate to complete cognitive tests
- Stable dose of oral atypical antipsychotic for at least 4 weeks
- Total PANSS score \> 60
- RBANS total score ≤ 80
- MMSE score of greater than or equal to 24
- Good physical health determined by physical examination, laboratory tests
- Capacity and willingness to give written informed consent
Exclusion
- Inability to read or speak English
- Documented disease of the central nervous system
- History of intellectual impairment pre-dating onset of symptoms of psychosis (e.g. mental retardation)
- Clinically significant or unstable cardiovascular, renal, hepatic, gastrointestinal, pulmonary or hematologic conditions
- HIV +
- Patients diagnosed with substance dependence
- Currently participating in another experimental study, except for the parent study.
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2016
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT00664274
Start Date
April 1 2007
End Date
October 1 2016
Last Update
April 17 2015
Active Locations (1)
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1
Manhattan Psychiatric Center
Wards Island, New York, United States, 10035