Status:
COMPLETED
Strength Training and Medication Effects in Parkinson Disease Effects on Hypokinesia in Parkinson Disease
Lead Sponsor:
University of Utah
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Parkinson Disease
Eligibility:
All Genders
40-90 years
Phase:
NA
Brief Summary
Parkinson disease is a degenerative neurologic condition characterized by slowness of movement, tremor, and loss of balance control. It results in significant degrees of disability for affected indivi...
Detailed Description
Idiopathic Parkinson disease (IPD) is the model movement disorder to explore the motor function of the basal ganglia. (Morris ME, 2005) Alterations in the output of the basal ganglia lead to reduction...
Eligibility Criteria
Inclusion
- male or a female at least 40 years of age or older neurologist diagnosed idiopathic PD (using UK Brain Bank Criteria) ambulatory and medically cleared by their physician to participate in an exercise regimen clinical signs of hypokinesia (reduced movement amplitude during ADL tasks) or postural instability have a Folstein Mini-Mental State Examination score \> 23 currently taking dopamine replacement medication
Exclusion
- previous surgical management of PD (pallidotomy, DBS) motor fluctuations and or dyskinesias uncontrolled by medications. central nervous system disorder (e.g., other than Parkinson's disease) myopathic disease (e.g., focal myopathy) that affects skeletal muscle structure/function rheumatological disease that has an effect on muscle and/or mobility unstable cardiovascular disease that limits exercise abilities impaired knee flexion, \<90 degrees, extreme claustrophobia (secondary to the inability to perform the MRI scans) regular (2-3x/week) aerobic or resistance exercise performed over the past 6 months
Key Trial Info
Start Date :
August 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00665184
Start Date
August 1 2007
End Date
July 1 2011
Last Update
September 21 2011
Active Locations (1)
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1
University of Utah Health Sciences Center
Salt Lake City, Utah, United States, 84108