Status:
COMPLETED
Implications for Treatment of the Metabolic Syndrome
Lead Sponsor:
University Hospital Southampton NHS Foundation Trust
Conditions:
Metabolic Syndrome
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
To characterize features of metabolic syndrome in volunteers. To undertake a randomised trial to determine whether treatment with a statin improves muscle microvascular blood flow.
Detailed Description
To characterise features of the metabolic syndrome, including body fat, insulin sensitivity, and liver fat together with muscle micorvascular blood flow. To undertake a randomised controlled trial of...
Eligibility Criteria
Inclusion
- Inclusion criteria Body mass index (BMI) 20-35 kg/m\^2" and "\> 3 criteria for the metabolic syndrome (NCEP III ATP criteria - see below) , one of which will be hypertriglyceridaemia, i.e. fasting plasma triglycerides \>2.0 mmol/L - a cardinal lipid abnormality of the syndrome
- NCEP III ATP metabolic syndrome criteria are:
- Waist greater than or equal to 102 cm BP greater than 130 / 85 mmHg TG greater than or equal to 1.7mmol/l Glucose greater than or equal to 6.1 mmol/l HDL less than 1.0 mmol/l
- Exclusion Criteria:
- Aged \<18 years Aged \>75 years Known diabetes; renal, liver, or uncontrolled thyroid disease; uncontrolled hypertension; treatment with lipid-modifying drugs; antihypertensive medication; corticosteroid therapy; or hormone replacement therapy.
Exclusion
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00666029
Start Date
February 1 2006
End Date
February 1 2008
Last Update
January 23 2019
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