Status:
COMPLETED
Familial Myeloproliferative Disorders
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
Myeloproliferative Disorders-Research Consortium
National Cancer Institute (NCI)
Conditions:
Polycythemia Vera
Essential Thrombocythemia
Eligibility:
All Genders
7+ years
Brief Summary
Myeloproliferative disorders occur in families, thus giving rise to the theory that it is a genetic disease that may be caused by an abnormal gene in the DNA that can be passed from one generation of ...
Eligibility Criteria
Inclusion
- Families with 2 or more members diagnosed with polycythemia vera (PV), essential thrombocythemia (ET), PV and ET related myelofibrosis (PV-MF and ET-MF), idiopathic myelofibrosis (IM) or chronic myelogenous leukemia (CML).
- Healthy family members of subjects diagnosed with a myeloproliferative neoplasm (MPN).
- Participating subjects must be 7 years of age or older
- A written assent, parental permission or consent must be obtained prior to any study procedures being performed.
Exclusion
- Subjects who have a known acquired cause of polycythemia (increased hemoglobin/hematocrit), such as people living in high altitudes (in excess of 14,000 feet), subjects with heart disease, left to right heart shunt, severe hypoxia, cyanotic congenital heart disease, or severe pulmonary disease, will be excluded from this study, secondary forms of thrombocytosis and secondary forms of myelofibrosis.
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 20 2015
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT00666289
Start Date
March 1 2008
End Date
June 20 2015
Last Update
September 5 2017
Active Locations (6)
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1
Georgetown University
Washington D.C., District of Columbia, United States, 20057
2
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
3
Mount Sinai School of Medicine
New York, New York, United States, 10029
4
Weill Cornell
New York, New York, United States, 10065