Status:
COMPLETED
Bipolar and Schizophrenia Consortium for Parsing Intermediate Phenotypes
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Schizophrenia
Bipolar
Eligibility:
All Genders
15+ years
Brief Summary
Briefly, this multisite study is designed to identify endophenotypes (i.e., heritable biomarkers) associated with either schizophrenia or bipolar disorder alone, or both together. The subsequent genet...
Detailed Description
We propose to recruit 100 case probands with a diagnosis of SZ, 100 case probands with a diagnosis of BP Disorder I with history of psychosis; BPI-P) and 400 1st degree case relatives. All 1st degree ...
Eligibility Criteria
Inclusion
- Male and female participants 15 years of age and above.
- Case probands will include individuals who meet DSM-IV criteria for schizophrenia, schizoaffective, or bipolar disorder with psychosis
Exclusion
- Control subjects who meet DSM-IV criteria for any lifetime psychotic illness or BP, or have a family history of psychotic or BP disorders in their first or second-degree relatives will be excluded.
- A number of exclusions are necessary because they potentially affect neurophysiological measures. Exclusions will be applied to all groups to maintain consistency in recruitment. As a result, the following individuals will be excluded:
- Subjects under 15 years of age will be excluded. Subjects with serious medical, neuro-ophthalmological or neurological illness (e.g., cancer, seizure disorders, encephalopathy) will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
- Subjects with current substance abuse (within 6 months), dependence within 2 years or extensive history of drug dependence will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
- Subjects with mental retardation will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
- Subjects with ferromagnetic objects lodged in body will be excluded, with the exception of family member subjects participating for clinical interview and blood sample only.
- Schizophrenic patients who are judged to be incompetent to provide voluntary informed consent based on the ESC evaluation.
- Any participant who would require an x-ray to rule out the presence of metal in their body prior to an MRI scan
Key Trial Info
Start Date :
May 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 22 2019
Estimated Enrollment :
3500 Patients enrolled
Trial Details
Trial ID
NCT00666432
Start Date
May 1 2008
End Date
November 22 2019
Last Update
May 3 2021
Active Locations (6)
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1
Hartford Hospital- The Institute of Living
Hartford, Connecticut, United States, 06106
2
Center for Cognitive Medicine
Chicago, Illinois, United States, 60612
3
Johns Hopkins School of Medicine
Baltimore, Maryland, United States, 21201
4
University of Maryland, Baltimore
Baltimore, Maryland, United States, 21228