Status:
COMPLETED
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women
Lead Sponsor:
University of Campania Luigi Vanvitelli
Conditions:
Obesity
Eligibility:
FEMALE
20-46 years
Phase:
NA
Brief Summary
Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue. To determine the effect of a program of ...
Eligibility Criteria
Inclusion
- obese premenopausal women,
- aged 20 to 46 years
- sedentary (\<1 h/wk of physical activity)
- with no evidence of participation in diet reduction programs within the last 6 months.
Exclusion
- type 2 diabetes mellitus or impaired glucose tolerance (plasma glucose levels of 140-200 mg/dL \[7.8-11.1 mmol/L\] 2 hours after a 75-g oral glucose load)
- hypertension (blood pressure \>140/90 mm Hg)
- cardiovascular disease, psychiatric problems
- history of alcohol abuse (intake of 500 g/wk in the last year)
- current smoking
- any medication use.
Key Trial Info
Start Date :
February 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2002
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00666874
Start Date
February 1 1999
End Date
February 1 2002
Last Update
April 25 2008
Active Locations (1)
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1
Department of Geriatrics and Metabolic Diseases
Naples, Italy, 80138