Status:
COMPLETED
Transcranial Direct Current Stimulation (tDCS) in Treatment-resistant Depression
Lead Sponsor:
Ludwig-Maximilians - University of Munich
Conditions:
Therapy Resistant Major Depression
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
tDCS applies a small amount of direct electric current (DC) to the brain by means of two electrodes: the one is an active electrode, localized on the effective site, and the other is a reference elect...
Detailed Description
Transcranial direct current stimulation (tDCS) is a non-invasive method that shifts membrane potential towards hypo- or hyperpolarization and therefore leads to functional changes in a discrete area o...
Eligibility Criteria
Inclusion
- Age 18-75 years
- At least moderate major depressive episode (DSM IV criteria).
- Stable total pre-treatment Hamilton Rating Scale for Depression score ≥18
- Therapy-resistance during current depressive episode (according to ATHF).
- The patient must be in the condition to understand the patient-information, as well as the necessary examinations. He/she must be able to give a written consent.
- Stable antidepressant medication, that is retained during the study- duration, from at least three weeks before the begin of the study.
Exclusion
- Existence of a care/legal incapacity
- Existing pregnancy
- Severe psychiatric illness (with exception of affective disorder)
- Acute suicidality
- Drug-, medication- or alcohol dependence
- Dementia according to DSM IV / ICD 10-criterions
- Severe TBI in the anamnesis
- Indications of structural damage of the basal ganglia or the brain stem
- Severe neurological disorders (e.g. M. Parkinson, epilepsy, discus-prolapse, dementia, systemic neurological illnesses, normal pressure hydrocephalus, cerebrovascular diseases, elevated intracranial pressure, in the last 6 months, polyneuropathies).
- Severe other medical conditions, like manifest arterial hypertonia, severe heart disease, pacemakers, respiratory failure, malignant illnesses all type, also in the history, active infectious diseases, skeletal disorders (like M. Paget, osteoporosis with spontaneous fractures, fresh fractures)
- Other circumstances, that speaks against a participation of the patient pinion of MD at this study.
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00667680
Start Date
March 1 2007
End Date
November 1 2008
Last Update
November 16 2009
Active Locations (1)
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1
Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University Munich
Munich, Germany, 80336