Status:
COMPLETED
Effect of Carvedilol Controlled-Release (CR) and Atenolol on Central Blood Pressure
Lead Sponsor:
University of Florida
Collaborating Sponsors:
GlaxoSmithKline
Conditions:
Hypertension
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this research study is to determine whether atenolol or controlled release carvedilol lower blood pressure in the body as effectively as in the arm. Blood pressure measured in the aorta...
Detailed Description
Carvedilol reduces aortic wave reflection and improves left ventricular/vascular coupling: a comparison with atenolol (CENTRAL Study) is a prospective, open-label, comparative, randomized control tria...
Eligibility Criteria
Inclusion
- At least 18 years of age
- Hypertension (untreated or treated with no more then one anti-hypertensive drug)
Exclusion
- Secondary forms of hypertension (including sleep apnea)
- Patients currently treated with two or more antihypertensive drugs
- Patients taking antihypertensive drugs with properly measured clinic systolic blood pressure greater then 170mmHg
- Isolated systolic hypertension
- Other diseases requiring treatment with blood pressure lowering medications
- Heart rate less then 55 beats/min (in the absence of beta-blocker therapy)
- Known cardiovascular disease including history of angina pectoris, heart failure, presence of a cardiac pacemaker, history of myocardial infarction or revascularization procedure, or cerebrovascular disease (including stroke and TIA)
- Known diabetes mellitus (Type 1 or 2)
- Renal insufficiency defined as a serum creatinine greater then 1.5mg/dL in males and 1.4mg/dL in females
- Primary renal disease
- Pregnancy or lactation
- History of Raynaud's syndrome
- Alcoholism and recreational drug use (due to compliance concerns)
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT00669279
Start Date
April 1 2008
End Date
July 1 2010
Last Update
October 5 2017
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32610