Status:
COMPLETED
Hypothermia to Prevent High Intracranial Pressure in Patients With Acute Liver Failure
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
University Hospital Birmingham
Northwestern University Feinberg School of Medicine
Conditions:
Acute Liver Failure
Intracranial Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Treatment options in patients with high intracranial pressure due to acute liver failure are limited. This study intends to evaluate the effect of prophylactic hypothermia on preventing high intracran...
Detailed Description
Acute liver failure (ALF) is associated with a high mortality. With severe hepatic encephalopathy and elevated arterial ammonia concentration (\< 200 micromol/L) more than 50% of the patients will dev...
Eligibility Criteria
Inclusion
- acute liver failure
- and hepatic encephalopathy stage 3 or 4
- and informed and written consent by closest relative(s)
- and arterial ammonia concentration above 150 micromol/L or clinical suspicion of cerebral edema
- and an ICP-measuring device
Exclusion
- no or withdrawn informed consent
- pregnant or breast feeding women
- uncontrollable infection
- hemodynamically instable patients
- active bleeding
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00670124
Start Date
January 1 2005
End Date
June 1 2011
Last Update
November 5 2014
Active Locations (4)
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1
Division of Hepatology, Feinberg School of Medicine, Northwestern University
Chicago, Illinois, United States, 60610
2
Department of hepatology, Rigshospitalet
Copenhagen, Denmark, 2100
3
Dept. of Intensive Care
Birmingham, United Kingdom
4
Institute for Liver Studies, King's College Hospital
London, United Kingdom