Status:
COMPLETED
Changes in Dopamine Levels Before and After Weight Restoration in People With Anorexia Nervosa
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Eating Disorders
Eligibility:
All Genders
18-45 years
Brief Summary
This study will use positron emission tomography imaging to investigate changes in dopamine systems in people with anorexia nervosa before and after weight restoration.
Detailed Description
Anorexia nervosa (AN) is a disordered eating disease characterized by a persistent pursuit of thinness, intense fear of weight gain, distorted body image, and obsessive eating habits. People with AN a...
Eligibility Criteria
Inclusion
- Participants with AN:
- Meets DSM-IV criteria for AN or ED-NOS (meets criteria for AN except amenorrhea)
- Sufficiently medically and psychiatrically stable to leave inpatient unit, as assessed by clinical team
- Healthy control participants:
- No current or past psychiatric illness
- Between 80% and 120% of ideal body weight
Exclusion
- All participants:
- Current use of psychotropic medication such as antipsychotics or antidepressants
- Pregnant or breastfeeding
- History of a substance use disorder
- Significant medical illness
- High blood pressure (resting systolic blood pressure greater than 140 mmHg and diastolic blood pressure greater than 90 mmHg)
- Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV-TR
- Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines
- Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry
- Previous adverse reaction to psychostimulants
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00670293
Start Date
July 1 2008
End Date
December 1 2015
Last Update
April 7 2016
Active Locations (1)
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1
New York State Psychiatric Institute
New York, New York, United States, 10032