Status:
COMPLETED
Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome
Lead Sponsor:
University of Michigan
Conditions:
Polycystic Ovary Syndrome
Eligibility:
FEMALE
21-40 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the effects of insulin resistance on brain function in women with Polycystic Ovary Syndrome (PCOS). PCOS affected women will be evaluated prior to and followin...
Detailed Description
The pathogenesis of Polycystic Ovary Syndrome (PCOS), a reproductive and metabolic disorder, is associated with insulin resistance. The effects of insulin resistance on cognition, mood, opioid system ...
Eligibility Criteria
Inclusion
- Insulin-resistant PCOS (Arm: PCOS Affected Women)
- Irregular menstrual cycle (Arm: PCOS Affected Women)
- Hyperandrogenism (Arm: PCOS Affected Women)
- Regular menstrual cycles (Arm: Normal Controls)
- Normal hormonal levels (Arm: Normal Controls)
- Lack of hirsutism (Arm: Normal Controls)
- Acne-free (Arm: Normal Controls)
- Candidates are BMI-matched and screened for insulin resistance prior to inclusion. (Arm: Normal Controls)
Exclusion
- Left handedness
- Acute medical illness
- Uncorrected thyroid disease
- Diabetes renal
- Cardiac or pulmonary insufficiency
- Active liver disease
- Neurological disease
- Current psychiatric illness
- Claustrophobia
- Contraindications to MRI
- Smoking
- Use of hormones
- Centrally acting or insulin sensitizing mediations
- Allergy to any opioid medication
- Substance abuse
- Pregnancy
- BMI \>35.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2009
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT00670800
Start Date
January 1 2008
End Date
August 1 2009
Last Update
May 21 2014
Active Locations (1)
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1
University of Michigan, Michigan Clinical Research Unit
Ann Arbor, Michigan, United States, 48109