Status:
TERMINATED
Differential Gene Expression in Lung and Peripheral Blood After Inhaled Allergen Challenge
Lead Sponsor:
John Sundy
Conditions:
Atopic Asthma
Healthy
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to identify the genes in important airway cells that are specifically expressed following inhalation of house dust mite allergen among study subjects with either allergic ...
Detailed Description
The purpose of this study is to identify the genes in airway epithelial and BAL cells that are differentially expressed following inhalation of house dust mite allergen among study subjects with aller...
Eligibility Criteria
Inclusion
- Allergic asthmatic, or nonallergic nonasthmatic
- Willing/able to give informed consent \& adhere to visit/protocol schedules.
- Screening visit laboratory, C-Xray, EKG, results within normal limits
- Women of childbearing potential must have a negative serum pregnancy test
- Screening Pulmonary function testing above study criteria parameters
Exclusion
- Systemic corticosteroid administration for asthma within the previous 90days
- Antibiotic administration within the previous 30 days.
- Viral respiratory infection within the previous 14 days.
- Allergen immunotherapy to House dust mite within the last 10 years
- History of severe asthma requiring intubation.
- Occupational exposure to hay or grain dust.
- Significant exposure history to cigarette smoke
- Past or present history of allergen immunotherapy to within the last 10 yrs
- Underlying illnesses that may result in altered lung function
- Students or employees under direct supervision by protocol investigators are ineligible
- Subjects allergic to medications used (or potentially used) in the study will be excluded.
- Subjects using aspirin will be excluded
- Subjects who abuse alcohol or illicit substances will be excluded
- Medication use other than for asthma, allergies or contraception
- Other medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
- Nursing mothers
- Other investigational medication within the last 30 days
Key Trial Info
Start Date :
October 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00671593
Start Date
October 1 2006
End Date
April 1 2009
Last Update
July 16 2013
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710