Status:
COMPLETED
Role of TLR4 in Environmental Asthma
Lead Sponsor:
John Sundy
Conditions:
Asthma
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
The overall goal of this project is to identify genes that are involved in the development of airflow obstruction and airway inflammation in asthmatics, and to determine whether polymorphisms in these...
Detailed Description
The overall goal of this project is to identify genes that are involved in the development of airflow obstruction and airway inflammation in asthmatics, and to determine whether polymorphisms in these...
Eligibility Criteria
Inclusion
- vital signs within normal limits
- negative methacholine challenge (non asthmatic)
- normal PFT's, CXR, EKG
- negative allergy skin tests (non atopic)
- never cigarette smoker
- no chronic illness
- no daily meds except contraceptives
- able and willing to sign informed consent
- not an employee working for,or a student under the authority of the PI's
Exclusion
- allergic rhinitis past or present
- chronic illness resulting in altered lung function
- chronic daily medications
- cigarette smoking
- allergy to acetaminophen or albuterol
- pregnant or nursing females
- PFT results below cut off
- Positive allergy skin test
- Abnormal CXR or EKG
- Positive methacholine challenge
- Infection in the previous 2 weeks
- Past or present allergen immunotherapy
- Occupational exposure to hay or grain
- Other medical or psychological conditions which, in the opinion of the PI, may create undue risk to the subject or interfere with the subject's ability to comply with protocol requirements.
Key Trial Info
Start Date :
September 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
855 Patients enrolled
Trial Details
Trial ID
NCT00671892
Start Date
September 1 2001
End Date
April 1 2008
Last Update
July 16 2013
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710