Status:
COMPLETED
Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence
Lead Sponsor:
Duke University
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Smoking
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in response inhibition during smoking abstinence. We will measure changes in performance and re...
Detailed Description
Participants will learn and practice a Go/No-Go reaction time task (Garavan, Hester, Murphy, Fassbender, \& Kelly, 2006) that measures inhibitory and excitatory aspects of behavioral control. During t...
Eligibility Criteria
Inclusion
- Smoker subjects must have
- smoked an average of 10 cigarettes per day for two continuous years of a brand that delivers (by Federal Trade Commission rated yields) at least 0.5 mg nicotine
- have an expired air carbon monoxide reading of at least 10 ppm.
- must be in general good health
- Non-smoker subjects must have
- smoked less than 50 cigarettes in their lifetime
- have not smoked in the last six months
- have an expired air carbon monoxide reading of less than or equal to 5 ppm.
- must be in general good health.
Exclusion
- major medical condition
- anything that would make participation unsafe (e.g., have pacemaker or other metallic implant) or uncomfortable (e.g., chronic pain)
- psychiatric condition
- suffering from claustrophobia
- current alcohol or drug abuse
- smokeless tobacco use, or use of nicotine replacement therapy or other smoking cessation treatment
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT00672256
Start Date
January 1 2007
End Date
March 1 2009
Last Update
July 23 2014
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27705