Status:
COMPLETED
Protocol to Assess the Severity of Acute Kidney Injury
Lead Sponsor:
George Washington University
Conditions:
Acute Kidney Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The principal objective is to safely determine if we can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease. Once enrolled, we will draw blood and urine for relevant...
Detailed Description
AKI is a very common disease in the intensive care unit. However, despite advances in supportive care, patients with AKI carry a high mortality rate (50% to 70%). The established AKI affects nearly 5 ...
Eligibility Criteria
Inclusion
- 18 years and older
- Increase in serum creatinine of 0.3 mg/dl within 48 hours or an increase of greater or equal to 150 to 200% from baseline or sustained oliguria(mean urine output of \<0.5 cc/kg/hr for 6 hours within 48 hours)
- Written informed consent
- Patients who already have a indwelling bladder catheter
Exclusion
- Voluntary refusal or missing written consent of the patient or the designated legal representative
- Patients with advanced Chronic Kidney Disease - as defined by a baseline GFR of \< 30 ml/min as calculated by the MDRD equation
- Patients with renal transplantation
- Pregnancy
- Patients with an allergy or sensitivity to loop diuretics
- Patients with a clinical syndrome consistent with pre-renal AKI
- Defined by fractional excretion of Na of \< 1% AND no evidence of the urinary casts, or
- Patients that are under-resuscitated as deemed by treating clinical team or
- Patients who are actively bleeding
- Patients with a clinical syndrome of post-renal AKI
- Any radiological study that shows hydro-ureter, or
- Clinical scenario wherein the obstruction is considered a likely possibility of the cause of AKI
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT00673244
Start Date
April 1 2008
End Date
December 1 2013
Last Update
October 18 2022
Active Locations (1)
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1
George Washington University Hospital
Washington D.C., District of Columbia, United States, 20037