Status:
COMPLETED
The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose
Lead Sponsor:
Forest Laboratories
Conditions:
Hypertension
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
This study is being done to see if the blood pressure and metabolic effects of an approved drug nebivolol is comparable to that of another approved drug hydrochlorothiazide (HCTZ) and placebo in hyper...
Detailed Description
This study is double blind (neither you nor the physician will know when you are receiving placebo, which is an inactive compound such as a sugar pill, or active study drugs nebivolol or hydrochloroth...
Eligibility Criteria
Inclusion
- Male or female, ambulatory outpatients 18-80 years old at screening.
- Have a history of hypertension and taking up to 2 medications for high blood pressure.
- Qualifying laboratory results confirming impaired fasting glucose or impaired glucose tolerance
- Vision and hearing (hearing aid permissible) sufficient for compliance with questionnaire completion
Exclusion
- Have clinically significant respiratory, liver or cardiovascular disease
- Presence of coronary artery disease requiring treatment with a beat blocker, calcium channel blocker or nitrates
- Use of niacin or antidiabetic drugs (oral or injectable) within 6 months before study entry
- Have a history of hypersensitivity to nebivolol, other beta-blockers, hydrochlorothiazide, or other sulfonamide-derived drugs.
Key Trial Info
Start Date :
May 15 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 9 2010
Estimated Enrollment :
537 Patients enrolled
Trial Details
Trial ID
NCT00673790
Start Date
May 15 2008
End Date
July 9 2010
Last Update
February 26 2020
Active Locations (88)
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1
Forest Investigative Site 058
Athens, Alabama, United States, 35611
2
Forest Investigative Site 101
Birmingham, Alabama, United States, 35215
3
Forest Investigative Site 016
Huntsville, Alabama, United States, 35801
4
Forest Investigative Site 119
Phoenix, Arizona, United States, 85020