Status:
COMPLETED
Pilot Study of Non-Invasive Assessment of Hepatic And Myocardial Iron Through T2* Magnet Resonance Imaging (MRI) In Patients With Iron Overload
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Hematological Diseases
Eligibility:
All Genders
7+ years
Brief Summary
Many hematological disorders are treated by giving red blood cells. Over a long period of time iron from the red blood cell will accumulate in the tissues of the heart, liver, and endocrine glands. Th...
Detailed Description
Quantitative measurements of hepatic and cardiac iron by single-breath-hold MRI T2\* will allow us to determine the value of this technique as a non-invasive method of monitoring liver and cardiac iro...
Eligibility Criteria
Inclusion
- Participant is greater than or equal to 7 years of age
- Participant needs a liver biopsy for monitoring iron overload
- Participant is willing to have magnetic resonance testing
Exclusion
- Patients with surgical clips placed in the United States after August 15th 1996 will be eligible to participate on the study.
- Contraindication to performing magnetic resonance testing, such as the presence of ferromagnetic material in the body
- Cannot tolerate an MRI without sedation or anesthesia.
Key Trial Info
Start Date :
October 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00675038
Start Date
October 1 2005
End Date
June 1 2008
Last Update
September 15 2011
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105