Status:
UNKNOWN
Micro- and Macrovascular Adaptations in Patients With Peripheral Arterial Disease During Supervised Exercise Therapy
Lead Sponsor:
Maastricht University Medical Center
Conditions:
PAOD (Peripheral Arterial Obstructive Disease)
Eligibility:
All Genders
18+ years
Brief Summary
Given that previous studies demonstrated the feasibility of the required MRI techniques, we propose to study the macro- and microvascular adaptations in PAOD patients undergoing supervised exercise th...
Eligibility Criteria
Inclusion
- Intermittent claudication according to a positive Rose-Edingburgh questionnaire
- Rest ankle-brachial pressure index (ABPI) \< 0,90 or 10% decline in ABPI after exercise
- Arterial stenosis/occlusion of femoro-popliteal territory according to duplex/MRA measurements
- Able to ondergo exercise therapy
Exclusion
- Chronic or acute critical ischemia
- Treated by or planned for vascular surgery or percutaneous transluminal angioplasty
- Recent onset \<2 months
- Unable to perform treadmill exercise
- Diabetes mellitus
- Contra-indications for (Gadolinium-enhanced) MRI or thigh cuff inflation
Key Trial Info
Start Date :
January 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2012
Estimated Enrollment :
117 Patients enrolled
Trial Details
Trial ID
NCT00675402
Start Date
January 1 2009
End Date
June 1 2012
Last Update
March 22 2011
Active Locations (1)
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1
Maastricht University Hospital
Maastricht, Limburg, Netherlands, 6202AZ