Status:
COMPLETED
The Natural History of Small Airways Physiology in Diseased and Healthy States
Lead Sponsor:
Imperial College London
Conditions:
Asthma
COPD
Eligibility:
All Genders
18-85 years
Brief Summary
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance. On the contrary, impulse oscillometry...
Detailed Description
Background The main objective of this study is to measure the damage of the small airways in lung disease exploring the "silent zone" with methods that have not been used before together in the same ...
Eligibility Criteria
Inclusion
- male or female, aged between 18-85 years;
- volunteers who are able to give written informed consent Patients meeting the diagnostic criteria for asthma, COPD, ILD, CF, chronic cough.
Exclusion
- upper respiratory tract infection within the previous 28 days
- any history or evidence of renal, cardiovascular, gastrointestinal or hepatic disease
- any history and evidence of neuropsychiatric disease
- treatment with antibiotics within 4 weeks prior to the study
- alcohol, drug abuse or any other condition associated with poor compliance
- breast feeding
- pregnancy
- are unable to provide written informed consent
Key Trial Info
Start Date :
June 22 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 10 2013
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT00677560
Start Date
June 22 2010
End Date
July 10 2013
Last Update
December 20 2021
Active Locations (1)
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1
Airway Disease Section, National Heart and Lung Institute, Imperial College
London, United Kingdom, SW3 6LY