Status:
COMPLETED
Simultaneous Versus Staged Resection for Initially Resectable Synchronous Rectal Cancer Liver-limited Metastasis
Lead Sponsor:
Fudan University
Conditions:
Rectal Neoplasm With Metastasis to the Liver
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the safety and efficacy of simultaneous liver resections compared to staged hepatectomies of rectal cancer with liver metastasis and to compare the short an...
Detailed Description
The optimal surgical strategy for treatment of patients with resectable synchronous rectal liver metastases remains controversial. To answer whether synchronous rectal cancer liver metastases (SLM) sh...
Eligibility Criteria
Inclusion
- age\>=18 and \<= 75 years
- resectable primary rectal tumor
- remnant liver volume \>= 60%
- without other organ metastasis or peritoneum metastasis
- without contradiction of cardiac and pulmonary diseases
- American Society of Anesthesiologists (ASA) class I - II
- Histologically proved rectal adenocarcinoma
Exclusion
- age \> 75 years
- unresectable primary rectal tumor
- remnant liver volume \< 60%
- with other organ metastasis or peritoneum metastasis
- with contradiction of cardiac and pulmonary diseases
- Tumors assessed as clinical complete response after preoperative radio- or chemoradiotherapy
- Signs of acute intestinal obstruction, bleeding or perforation needing emergency surgery
- Multiple colorectal tumors or other schedules needing for synchronous colon surgery
- Co-existent inflammatory bowel disease
- Pregnancy or lactation
- Patients received treatment other than preoperative radio- or chemoradiotherapy
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2022
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT00677586
Start Date
July 1 2010
End Date
July 1 2022
Last Update
July 7 2022
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