Status:
COMPLETED
Hypertonic Saline to Reduce Hospital Admissions in Bronchiolitis
Lead Sponsor:
Queen's University
Collaborating Sponsors:
Kingston Health Sciences Centre
Religious Hospitallers of Saint Joseph of the Hotel Dieu of Kingston
Conditions:
Viral Bronchiolitis
Eligibility:
All Genders
Up to 24 years
Phase:
PHASE2
Brief Summary
Inhaled 3% hypertonic saline (HS) administered every 2-8 hours to infants admitted to hospital with viral bronchiolitis has been shown to improve airway clearance and reduces length of stay. Hypothes...
Detailed Description
Patients presenting to the Emergency Room (ER) or out-patient department with a diagnosis of moderately severe bronchiolitis (as defined by inclusion/exclusion criteria below) will be approached for e...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- \< 24 months.
- presenting to ER or outpatient department with moderately severe viral bronchiolitis defined as:
- history of viral upper respiratory tract infection within previous 7 days, plus
- presence of wheezing and/or crackles on chest auscultation, plus
- Respiratory Distress Assessment Instrument (RDAI, appendix B) score \> 4 (of 17) or transcutaneous oxygen saturation (SaO2) \< 94% in room air.
- Patient exclusion criteria:
- history of immunodeficiency or chronic cardiopulmonary disease (other than past history of wheezing).
- critical illness at presentation.
- use of nebulized HS within previous 12 hr.
- prematurity (gestational age \< 34 weeks).
Exclusion
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT00677729
Start Date
November 1 2008
End Date
May 1 2009
Last Update
November 13 2015
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
The Royal Victoria Hospital
Barrie, Ontario, Canada, L4M 6M2
2
Kingston General Hospital
Kingston, Ontario, Canada, K7L 2V7
3
Religious Hospitallers of Saint Joseph of the Hotel Dieu of Kingston
Kingston, Ontario, Canada