Status:
COMPLETED
P-glycoprotein Function in Brain Diseases
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Alzheimer Disease
Parkinson Disease
Eligibility:
All Genders
35+ years
Brief Summary
This study will measure the function of a protein called P-glycoprotein (P-gp), which is found at the blood-brain barrier, a membrane that normally prevents toxic material from entering the brain. Imp...
Detailed Description
Objective Alzheimer disease (AD), Parkinson disease (PD), and frontotemporal dementia (FTD) are associated with the accumulation of neurotoxic material in the brain. Potentially toxic material is nor...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Patients with the diagnosis of probable Alzheimer disease, Parkinson disease, or frontotemporal dementia. All patients must either meet capacity criteria to consent to research, or be able to assign a surrogate decision-maker who is able to consent to research on the subject s behalf.
- Healthy volunteers.
- EXCLUSION CRITERIA:
- Current psychiatric disease, substance abuse or severe systemic disease based on history and physical exam.
- Laboratory tests with clinically significant abnormalities.
- Subjects on blood-thinning medications, having coagulation disorders, or clinically significant abnormal blood clotting test (PT/PTT).
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure, including that from this protocol, would exceed the guidelines set by the Radiation Safety Committee (RSC).
- Pregnancy or breast feeding.
- Positive result on urine screen for illicit drugs.
- Subjects who cannot lie on their back for extended periods of time.
- History of neurological disease other than Alzheimer disease, Parkinson disease, or frontotemporal dementia.
- Subjects who have a cardiac pacemaker or metal in their body.
- Subjects taking cyclosporine A.
Exclusion
Key Trial Info
Start Date :
May 9 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 25 2014
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00677885
Start Date
May 9 2008
End Date
August 25 2014
Last Update
November 22 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892