Status:
COMPLETED
Study Using High-Dose Single Fraction Image-Guided Radiotherapy for Metastatic Lesions to Soft Tissue Masses, Lymph Node, or Bone
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Conditions:
Metastatic Disease
Eligibility:
All Genders
18-85 years
Phase:
PHASE1
Brief Summary
The purpose of this research study is to find out what IG-IMRT radiation dose works best for treatment of disease in bone or soft tissues. This protocol will study what dose level may work most effect...
Eligibility Criteria
Inclusion
- Biopsy-proven cancer verified at MSKCC
- Imaging evidence of lymph node metastases, bone metastases or soft tissue disease
- Age \> or = to 18 years
- KPS \> or = to 80
- Epidural disease is acceptable as long as the dose to the spinal cord ≤ 14 Gy
- Able to tolerate immobilization cradle positioning
Exclusion
- Target lesion not visible on conventional CT scan
- Unable to be administered intravenous CT contrast safely
- Prior radiation to the planned target region. A second metastatic lesion would not be eligible if the area received or will receive any dose (5% or greater isodose line)from a prior or planned single fraction treatment
- Patients receiving concurrent chemotherapy (within 1 week of RT)
- Normal tissue directly overlying target precluding ability to limit the bowel, bladder, rectum or other tissue to 15-16 Gy dose constraints
- Weight-bearing bones with significant cortical destruction from tumor. In these cases, patients will be referred for orthopedic consultation for rod stabilization procedures.
- Subjects with more than 4 metastases to bone
- Any metastatic lesion larger than 8 cm in its greatest diameter
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT00678158
Start Date
August 1 2006
End Date
November 1 2015
Last Update
November 17 2015
Active Locations (1)
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1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065