Status:
COMPLETED
To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis
Lead Sponsor:
Brian J Lipworth
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
16-75 years
Phase:
PHASE4
Brief Summary
Allergic rhinitis is a common condition characterize by inflammation of the upper airways. Third generation antihistamines have been demonstrated effective in the treatment of this condition. Allergen...
Eligibility Criteria
Inclusion
- Male or female 16-75
- Patients with persistent rhinitis must be skin prick positive to house dust mite with perennial symptoms
- Patients with seasonal rhinitis should be skin prick positive to grass/tree pollen with seasonal symptoms
- Concomitant asthma is permitted in those with rhinitis if FEV1 \>60%
- No recent exacerbations of asthma or chest infections if asthmatic
- Able to perform all of the techniques necessary to carry out challenge testing
- Must be compliant to study medication
- Must give informed consent
Exclusion
- Male or female outwith the above age range
- Negative skin prick testing
- Patients with concomitant asthma with FEV1 less than 60% predicted
- Patients with asthma with recent chest infection or exacerbation
- Pregnant females, those at risk of becoming pregnant or breast feeding. Females must be on adequate contraception for the whole study period
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00679250
Start Date
November 1 2005
End Date
December 1 2006
Last Update
April 12 2019
Active Locations (2)
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1
Ninewells Hospital and Medical School (Tayside NHS Trust, University of Dundee)
Dundee, Angus, United Kingdom, DD1 9SY
2
Perth Royal Infirmary
Perth, Perthshire, United Kingdom, PH1 1NX