Status:
COMPLETED
Topical IL-1-Ra for Treatment of Posterior Blepharitis
Lead Sponsor:
Reza Dana, MD
Conditions:
Posterior Blepharitis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine the effectiveness and safety of Topical Interleukin-1-Receptor Antagonist in treatment of signs and symptoms of posterior blepharitis.
Eligibility Criteria
Inclusion
- A diagnosis of posterior blepharitis
- A negative urine pregnancy test result for women of childbearing potential
- Women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation
- Normal lid position and closure
- Ability to understand and provide informed consent to participate in this study
- Willingness to follow study instructions and likely to complete all required visits.
Exclusion
- History of Stevens-Johnson syndrome or ocular pemphigoid
- History of eyelid surgery
- Intra-ocular surgery or ocular laser surgery within 3 months
- History of microbial keratitis, including herpes
- Active ocular allergies
- Corneal epithelial defect \> 1mm2
- Use of topical steroids or Restasis within the past 2 weeks
- Use of tetracycline compounds (tetracycline, doxycycline, and minocycline) within the last month
- Use of isotretinoin (Accutane) within the past 6 months
- Have had any previous treatment with Anakinra (Kineret®) or any therapeutic agent targeted at IL-1 blockade
- Pregnant or lactating women
- Signs of current infection, including fever and current treatment with antibiotics
- Liver, renal, or hematologic disease
- The use of any other investigational drug
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00681109
Start Date
January 1 2008
End Date
October 1 2010
Last Update
January 19 2018
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