Status:
COMPLETED
Sex Differences in Vascular Markers of Stroke Risk
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Stroke
Eligibility:
All Genders
45-65 years
Brief Summary
The purposes of this study are to quantify and compare vascular function in men and women, and to determine the effect of age, race-ethnicity, cardiovascular risk factors, biological markers and hormo...
Detailed Description
Men and women with stroke have different risk factor profiles. Women tend to develop stroke risk factors, subclinical disease, and have vascular events following menopause, presumably related to the d...
Eligibility Criteria
Inclusion
- One or more cardiovascular risk factors
- non-insulin dependent diabetes
- hypertension
- hyperlipidemia
- metabolic syndrome, (NCEP ATPIII criteria)
- tobacco smoking
Exclusion
- history of prior stroke (ischemic or hemorrhagic)
- TIA
- known carotid stenosis
- peripheral vascular disease
- coronary heart disease
- venous thromboembolism
- polycystic ovarian syndrome,
- morbid obesity (BMI \> 45 kg/m2)
- women using hormone therapy (hormone replacement, contraceptive pills or patches)
Key Trial Info
Start Date :
February 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
117 Patients enrolled
Trial Details
Trial ID
NCT00681681
Start Date
February 1 2008
End Date
January 1 2013
Last Update
November 8 2017
Active Locations (1)
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1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157-1043