Status:
COMPLETED
Redox State in the Course of Chronic Renal Insufficiency and Hemodialysis: Implications in Morbimortality
Lead Sponsor:
Assistance Publique Hopitaux De Marseille
Conditions:
Chronic Renal Insufficiency
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The influence of hemodialysis on oxidative stress, endothelial activation, inflammation and on the redox state of lymphocytes should be clarified as well as the putative relationships between all thes...
Detailed Description
Up to now, no anti-oxydative treatment has been able to reduce the mortality of the patients with Kidney Failure. Thus it is necessary to have a better knowledge of oxydative stress mechanisms in pati...
Eligibility Criteria
Inclusion
- 18 and 80 years old man or woman dialysing at least 3 times a week for at least 6 months and having no residual renal function
- Rate of haemoglobin \> 11 g / dl
- Clinically stable patient that is having had no considerable event (cardiovascular problem, infection, surgical operation) with the exception of angioplasty of fistula or prosthesis vascular, in the previous 3 months the entrance to the study
- Patient capable of understanding and of following the essay, in particular knowing how to read the note of information.
Exclusion
- Pregnant woman
- Treatment by corticoids or immunosuppresseurs
- hemopathy sly
- chronic cancer or infection in evolution
- Cardiovascular event (infarct, unstable angor, coronary bypasses, confusions of the rhythm, AVC, amputation) or infectious (blood-poisoning, pneumopathie, meningitis) or surgical operation in the previous 3 months the inclusion in the study.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
131 Patients enrolled
Trial Details
Trial ID
NCT00684034
Start Date
June 1 2008
End Date
April 1 2012
Last Update
August 28 2014
Active Locations (1)
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1
Hopital de la Conception- Service de Néphrologie et de transplantation rénale
Marseille, France, 13385