Status:
COMPLETED
Effects of Stress and Other Factors on Opiate Drug Choice.
Lead Sponsor:
Wayne State University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Heroin Dependence
Opioid-Related Disorders
Eligibility:
All Genders
18-55 years
Brief Summary
The purpose is to study the extent to which stress and other factors, including money, the amount of drug available and the amount of work effort, affect drug choice. This study will assess whether e...
Detailed Description
Physical, environmental, and pharmacological stressors have been repeatedly shown to increase self-administration of various abused substances in both preclinical and human studies. The primary aim of...
Eligibility Criteria
Inclusion
- Opioid dependent, as determined by structured clinical interview for DSM-IV (SCID) and Addiction Severity Index (ASI)
- Positive urine test for opiates
- Willing to use an adequate form of contraception for the duration of the study.
- Reads and writes English
Exclusion
- Psychiatric illness, as determined by the DSM-IV criteria
- History of or current neurological disease, including structural abnormalities, seizures, infection, peripheral neuropathy, and head traumas
- History of cardiovascular disease, myocardial infarction, chest pain, or edema
- Systolic blood pressure greater than 160mm HG or less than 95 mm HG: PR diastolic blood pressure greater than 95 mm HG.
- Pulmonary disease, including obstructive pulmonary disease, Cor pulmonale, tuberculosis, and asthma
- Systemic disease (e.g. endocrinopathies, liver or kidney failure, myxedema, hypothyroidism, Addison's disease, autoimmune disease)
- Current alcohol or sedative drug dependence
- Pregnant or breast feeding
- Currently receiving treatment for opioid dependence
- Known phobia of injections
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2011
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00684840
Start Date
March 1 2008
End Date
December 1 2011
Last Update
June 5 2012
Active Locations (1)
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1
Wayne State University
Detroit, Michigan, United States, 48202