Status:
COMPLETED
HIV-1 Viral Dynamics in Subjects Initiating Raltegravir Therapy in Spain
Lead Sponsor:
Germans Trias i Pujol Hospital
Collaborating Sponsors:
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Conditions:
HIV Infections
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The study purpose is to investigate plasma HIV-1 RNA dynamics in subjects initiating raltegravir-based salvage therapy and quantify the corresponding changes in levels of cellular HIV-1 DNA.
Detailed Description
First- and second-phase decay rates of plasma HIV-1 RNA and changes in the intracellular levels of HIV-1 proviral DNA and LTR circles will be measured in subjects starting salvage antiretroviral thera...
Eligibility Criteria
Inclusion
- Patients who have limited or no treatment options due to extensive antiretroviral drug resistance or drug intolerance.
- Subjects initiating raltegravir plus another fully active antiretroviral drug.
Exclusion
- Pregnancy, or fertile women willing to be pregnant.
- Active substance abuse or major psychiatric disease.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00685191
Start Date
June 1 2008
End Date
October 1 2009
Last Update
December 4 2019
Active Locations (1)
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1
Hospital U. Germans Trias i Pujol
Badalona, Barcelona, Spain, 08916