Status:
COMPLETED
Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic Disorders
Lead Sponsor:
Corewell Health West
Collaborating Sponsors:
Van Andel Research Institute
Community Foundation for Southeast Michigan (JP McCarthy Fund)
Conditions:
Myeloproliferative Disorder
MDS
Eligibility:
All Genders
18+ years
Brief Summary
Aim of the study is to analyze the expression of genes and sequences encoding the human mammalian diaphanous (mDia) related formin proteins to test the hypothesis that defects in the mDia expression o...
Detailed Description
Leukocytes and myeloid lineage cells from these specimens will be assayed for expression of DRF genes using standard molecular biological approaches to measure mRNA levels. Extracted DNA will be analy...
Eligibility Criteria
Inclusion
- 18 and over
- Male
- Female
- Diagnosed with MDS, MPD and AML
Exclusion
- Under the age of 18
- Received bone marrow transplant
- Control Group Criteria:
- inclusion:
- healthy men and women
- ≥ 55 years of age
- exclusion:
- history of hematological condition
- history of cancer
Key Trial Info
Start Date :
April 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00687414
Start Date
April 1 2008
End Date
January 1 2010
Last Update
July 27 2023
Active Locations (2)
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1
St Mary's Health Care
Grand Rapids, Michigan, United States, 49503
2
Van Andel Research Institute
Grand Rapids, Michigan, United States, 49503