Status:
COMPLETED
Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
Lead Sponsor:
Danish Headache Center
Collaborating Sponsors:
EUROHEAD
Conditions:
Familial Hemiplegic Migraine
Migraine With Aura
Eligibility:
All Genders
Phase:
NA
Brief Summary
The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.
Detailed Description
Calcitonin gene-related peptide (CGRP) induces migraine attacks indistinguishable from spontaneous attacks in a large proportion of migraine sufferers. Treatment of spontaneous migraine attacks with a...
Eligibility Criteria
Inclusion
- Diagnosis of familial hemiplegic migraine (IHS-classification criteria)
- Diagnosis of migraine with aura(IHS-classification criteria)
- Healthy controls
Exclusion
- Patients and controls:
- A history of cerebrovascular disease and other CNS- disease
- A history of serious somatic and mental disease
- A history suggesting ischaemic heart disease
- A history of hypo- or hypertension
- Daily intake of medication apart from oral contraceptives
- Abuse of alcohol or medicine (opioid analgesics).
- Pregnant or breastfeeding women.
- On the study day:
- No intake of a simple analgesic in the previous 48 hours
- No headache in the previous 48 hours
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00687947
Start Date
May 1 2008
End Date
August 1 2008
Last Update
August 3 2009
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Danish Headache Center, University of Copenhagen, Faculty of Health Sciences, Department of Neurology, Glostrup Hospital
Glostrup, Copenhagen, Denmark, 2600