Status:
COMPLETED
Evaluation of Renal Drug Transport in Healthy Volunteers
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Conditions:
Kidney Disease
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The process of drug elimination that occurs within the kidneys is complex, and involves filtration, secretion and absorptive mechanisms. Many drugs, metabolites and toxins, including organic anions an...
Detailed Description
The purpose of this study is to measure GFR (using iothalamate clearance) and renal tubular function (using PAH clearance) in healthy subjects. The protocol will be approved by the University of Maryl...
Eligibility Criteria
Inclusion
- Adult, aged 18 to 40 years
- Healthy based on review of past medical history and physical examination (normal biochemical screen and urinalysis)
- Signed inform consent
Exclusion
- Any medications taken within 48 hours prior to study
- History of gout or gouty arthritis
- History of uric acid
- Kidney stones
- History of known allergic or adverse reactions to diagnostic iodine containing compounds including iothalamate, PAH or probenecid, will be excluded.
- Subjects with current or preexisting liver disease (including hepatitis) as evidenced by elevated INR, liver transaminases (AST/ALT), bilirubin, or serum albumin \< 3.0 g/dL.
Key Trial Info
Start Date :
August 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00690014
Start Date
August 1 2006
End Date
June 1 2007
Last Update
May 11 2021
Active Locations (1)
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1
University of Maryland GCRC
Baltimore, Maryland, United States, 21201