Status:
COMPLETED
Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers
Lead Sponsor:
Children's Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Extraocular Retinoblastoma
Intraocular Retinoblastoma
Eligibility:
All Genders
Brief Summary
This laboratory study is looking at genetic mutations and environmental exposure in young patients with retinoblastoma and in their parents and young healthy unrelated volunteers. Gathering informatio...
Detailed Description
OBJECTIVES: I. To investigate the role of genotypes for carcinogen metabolizing enzymes (CME) and DNA repair proteins(DRPs) of the father of children diagnosed with retinoblastoma (RB) and his enviro...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Cases must meet the following criteria:
- Diagnosed with sporadic retinoblastoma (RB) on or after 07/01/2006
- No familial retinoblastoma
- Have permission of physician to contact the parents
- Diagnosed and/or treated at a Children's Oncology Group (COG) institution or \*Wills Eye Hospital
- Controls must meet 1 of the following criteria:
- Mother of a child with unilateral RB
- Father of a child with bilateral RB
- Age-matched non-blood-related child if possible
- Must reside in the U.S. or Canada
- Must have telephone in the home
- Biological parent speaks English or Spanish
- Concurrent treatment on a therapeutic trial is NOT required
Exclusion
Key Trial Info
Start Date :
June 2 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT00690469
Start Date
June 2 2008
Last Update
October 8 2019
Active Locations (52)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
2
Children's Hospital Central California
Madera, California, United States, 93636-8762
3
UCSF Medical Center-Mount Zion
San Francisco, California, United States, 94115
4
UCSF Medical Center-Parnassus
San Francisco, California, United States, 94143