Status:
COMPLETED
Insulin and Sarcopenia in the Elderly
Lead Sponsor:
The University of Texas Medical Branch, Galveston
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Sarcopenia
Eligibility:
All Genders
18-85 years
Phase:
PHASE1
Brief Summary
Muscle loss with aging is a significant contributor to disability in older people. Our general hypothesis is that loss of muscle with aging, known as sarcopenia, may be due to inability of muscle to g...
Detailed Description
Our general hypothesis is that a reduced response of muscle protein anabolism to insulin plays an important role in the loss of muscle mass with aging. Our goal is to determine the mechanisms underlyi...
Eligibility Criteria
Inclusion
- Age 18-40 yrs, and 65-85 yrs.
- Ability to sign consent form (score \>23 on the 30-item Mini Mental State Examination, MMSE)
- Stable body weight for at least 3 months
Exclusion
- Physical dependence or frailty (impairment in any of the Activities of Daily Living (ADL), history of falls (\>2/year) or significant weight loss in the past year)
- Exercise training (\>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
- Pregnancy or nursing women.
- Significant heart, liver, kidney, blood or respiratory disease
- Peripheral vascular disease
- Diabetes mellitus or other untreated endocrine disease
- Active cancer
- Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
- Alcohol or drug abuse
- Severe depression (\>5 on the 15-item Geriatric Depression Scale, GDS)
- Potential subjects who have recently donated blood in the past 60 days will be excluded from participating in the study.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT00690534
Start Date
September 1 2005
End Date
August 1 2012
Last Update
December 12 2016
Active Locations (1)
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1
Sealy Center on Aging, University of Texas Medical Branch
Galveston, Texas, United States, 77555-0460