Status:
UNKNOWN
A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide
Lead Sponsor:
Oregon Health and Science University
Conditions:
Obesity
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
The purpose of this study is to identify how certain parts of the brain that help control body weight respond to an infusion of hormones called leptin and amylin.
Detailed Description
Following an overnight fast, subjects will undergo fMRI measurements of the hypothalamus, brainstem and whole brain during an infusion of either normal saline, pramlintide, leptin, or the combination ...
Eligibility Criteria
Inclusion
- Age 18 year to 45 years of age
- MI 18 to 25 kg/m2 or ≥ 30 kg/m2
- At maximal lifetime weight
- Weight stable for at least 3 months
Exclusion
- Those with a major medical illness or who require prescription medication, including: cancer, coronary artery disease, hypertension, and diabetes.
- Subjects taking psychiatric or centrally-acting (CNS) medications or who are diagnosed with a psychiatric or neurological illness, including:
- depression
- anorexia
- bulimia
- seizure disorder.
- Exercise \> 30 minutes, 3 times a week
- Alcohol consumption \> 2 drinks / day
- Weight \> 350 lbs (159 kg) (weight limit for MR machine)
- Illicit drug use
- Pregnancy
- Extreme dietary habits as determined by a GCRC nutritionist: very high or low dietary carbohydrate or fat intakes
- Those with a contraindication to exposure to strong magnetic fields: presence of metal in the body such as body piercing, shrapnel, cardiac pacemakers or aneurysm clips
- Those with claustrophobia
- Anaphylaxis and known hypersensitivity to E. coli-derived proteins
- Allergies or contraindications to metreleptin or pramlintide
- Renal or hepatic impairment
- Women who are lactating
- Tobacco use
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00691158
Start Date
January 1 2006
End Date
July 1 2024
Last Update
December 16 2022
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239