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Status:

COMPLETED

Kidney and Blood Pressure Changes in Patients Receiving Bevacizumab, Aflibercept, Sunitinib, or Cediranib for Cancer

Lead Sponsor:

University Health Network, Toronto

Collaborating Sponsors:

National Cancer Institute (NCI)

Conditions:

Unspecified Adult Solid Tumor, Protocol Specific

Eligibility:

All Genders

18+ years

Brief Summary

This research study is looking at kidney and blood pressure changes in patients receiving bevacizumab, aflibercept, sunitinib, or cediranib for cancer. Studying samples of blood and urine from patient...

Detailed Description

OBJECTIVES: I. To study the renal and blood pressure changes in patients treated with bevacizumab, aflibercept, sunitinib malate, or cediranib for their cancer. II. To determine the physiological me...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Planning to start treatment with one of the following antiangiogenic drugs as single agents or in combination with chemotherapy for their cancer:
  • Cediranib (AZD2171 )
  • Bevacizumab (Avastin)
  • Sunitinib (Sutent)
  • Aflibercept (VEGF Trap)
  • Urinalysis negative for protein OR 24-hour urine for protein \< 500 mg
  • Prior chemotherapy within the past 12 months allowed
  • More than 12 months since prior antiangiogenic drugs, including monoclonal antibodies that bind to VEGF or tyrosine kinase inhibitors that block VEGFR2
  • At least 6 weeks since prior and no concurrent aldosterone receptor antagonists (e.g., spironolactone \[aldactone\] or eplerenone)
  • No other concurrent investigational agents

Exclusion

    Key Trial Info

    Start Date :

    February 1 2008

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    April 1 2019

    Estimated Enrollment :

    52 Patients enrolled

    Trial Details

    Trial ID

    NCT00691730

    Start Date

    February 1 2008

    End Date

    April 1 2019

    Last Update

    January 27 2021

    Active Locations (4)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 1 (4 locations)

    1

    Tom Baker Cancer Centre

    Calgary, Alberta, Canada, T2N 4N2

    2

    London Regional Cancer Program

    London, Ontario, Canada, N6A 4L6

    3

    Mount Sinai Hospital

    Toronto, Ontario, Canada, M5G 1X5

    4

    University Health Network-Princess Margaret Hospital

    Toronto, Ontario, Canada, M5G 2M9