Status:
COMPLETED
Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease
Lead Sponsor:
Paracelsus Medical University
Conditions:
Type 2 Diabetes Mellitus
Coronary Artery Disease
Eligibility:
All Genders
50-80 years
Phase:
PHASE4
Brief Summary
Patients with type 2 diabetes mellitus suffer from accelerated coronary artery disease. We will assess the effects of exercise training on coronary endothelial function, vascular structure, and inflam...
Eligibility Criteria
Inclusion
- written informed consent
- preserved left ventricular function (left ventricular ejection fraction ≥ 50%)
- a physical work capacity ≥ 50 W
- at least one significant coronary stenosis \> 50%, whereas either the left anterior descending (LAD) or circumflex artery (RCX) has to be free from disease or stenoses ≤ 25% for the assessment of intracoronary flow measurements
Exclusion
- diseases further affecting endothelial function
- untreated hypertension (systolic blood pressure \> 160 mm Hg or a diastolic blood pressure of \> 90 mm Hg)
- cigarette smoking during the previous six months
- LDL-cholesterol \> 4.3 mmol/l
- ventricular tachyarrhythmias
- chronic obstructive pulmonary disease
- severe renal or hepatic dysfunction
- valvular heart disease
- myocardial infarction within the previous 4 weeks
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00693537
Last Update
August 30 2019
Active Locations (1)
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1
University Institute of Sports Medicine, Prevention and Rehabilitation
Salzburg, Austria, 5020