Status:
COMPLETED
Working Memory Performance Among Childhood Brain Tumor Survivors
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Brain Tumors
Eligibility:
All Genders
8-18 years
Brief Summary
Children treated with radiation therapy for brain tumors are at risk for cognitive problems. These problems have typically been demonstrated on global cognitive measures including measures of intellec...
Detailed Description
This is a cross-sectional controlled study of brain tumor survivors treated at St. Jude with conformal radiation therapy. Brain tumor survivors (n= 50, solid tumor survivors (n=40), and healthy siblin...
Eligibility Criteria
Inclusion
- Brain Tumor Patients
- Treated for a primary central nervous system (CNS) tumor with conformal radiation therapy and enrolled on the institutional protocol RT-1
- Initiated radiation therapy at least 2 years prior to enrollment with no evidence of recurrent disease
- Age 8-18 years inclusive at the time of enrollment, with sampling to obtain a broad cross-section of participants in terms of age, tumor location and time since RT initiation
- English as the primary language
- Research participant and one parent willing to participate and provide consent/assent according to institutional guidelines
- Solid Tumor Patient Controls
- Treated for a solid tumor (i.e., Ewing's sarcoma, osteosarcoma, soft tissue/rhabdomyosarcoma, neuroblastoma or Wilms tumor) at St. Jude without CNS directed therapy - Diagnosed at least 2 years prior to enrollment
- Age 8-18 inclusive at the time of enrollment, with age, gender and race sampling to broadly match the brain tumor group
- English as the primary language
- Research participant and one parent willing to participate and provide consent/assent according to institutional guidelines
- Sibling Controls
- Healthy sibling controls- siblings of St. Jude patients treated for a brain tumor (not necessarily on RT-1)
- Age 8-18 inclusive, with age and gender sampling to broadly match the patient group
- English as a primary language
- Research participant and one parent willing to participate and provide consent/assent according to institutional guidelines
Exclusion
- Brain Tumor Patients
- Significant impairment in global intellectual functioning (operationalized as an estimated IQ less than 70 as indicated by most recent RT-1 testing)
- History of documented CNS injury or disease predating cancer diagnosis
- History of documented Attention Deficit Hyperactivity Disorder (ADHD) predating cancer diagnosis by at least one year (must have been diagnosed by a physician with medication prescribed)
- Treatment with psychostimulant or psychotropic medication within two weeks of study enrollment
- Sensory or motor impairment that would preclude valid cognitive testing
- Solid Tumor and Sibling Controls
- Significant impairment in global intellectual functioning (operationalized as a history of special education in a self-contained classroom)
- History of documented CNS injury or disease
- History of documented Attention Deficit Hyperactivity Disorder (ADHD) (must have been diagnosed by a physician with medication prescribed)
- Treatment with psychostimulant or psychotropic medication within two weeks of study enrollment
- Sensory or motor impairment that would preclude valid cognitive testing
Key Trial Info
Start Date :
April 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT00693914
Start Date
April 1 2007
End Date
December 1 2009
Last Update
April 25 2017
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105