Status:
COMPLETED
Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease
Lead Sponsor:
Centre Hospitalier Universitaire de Saint Etienne
Collaborating Sponsors:
ARGOS
Association de la Vallée de l'Ondaine
Conditions:
Placental Vascular Pathologies
Venous Thromboembolism Diseases
Eligibility:
FEMALE
16-50 years
Brief Summary
Venous thromboembolic (VTE) disease is the first cause of maternal mortality in the world. Some other pregnancy pathologies called Placental Vascular Pathologies (PVP) are linked to VTE by biological ...
Detailed Description
Main aim: To evaluate echographic, doppler and biological markers in a prospective manner as a potential predictive factor of risk of PVP and VTE.
Eligibility Criteria
Inclusion
- previous history of one or more PVC episodes (preeclampsia, HELLPs, retroplacental hematoma, vascular IUGR\<10th percentile, recurrence miscarriage \>2, unexplained IUFD or IUFD after abruption placentae, eclampsia.
- Previous history of personal VTE
- Diabete (treated with diet or insulin)
- chronic hypertension
- chronic renal pathology
- lupus
- obesity
- Antihopholipids syndrome
- early and late pregnancy (\<18 years, \>38 years)
- family history of cardiovascular disease of VTE
- known biological thrombophilia without any personal past history of PVC or VTE
Exclusion
- Multiple pregnancy
- past history of in utero fetal death due to congenital malformations, rhesus incompatibility or an infection
- previous history of IUGR which etiology was a chromosomal, genic or infectious anomaly
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00695942
Start Date
June 1 2008
End Date
May 1 2012
Last Update
May 17 2012
Active Locations (3)
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1
Service d'Hématologie - CHU de Nîmes
Nîmes, France, 30000
2
Service de gynécologie Obstétrique
Nîmes, France, 30000
3
Service de Gynécologie Obstétrique - CHU Saint-Etienne
Saint-Etienne, France, 42055