Status:
COMPLETED
Effects of Butyrate on Colonic Health of Patients With Diarrhoea Predominant IBS and UC in Remission
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
Top Institute Food and Nutrition
Conditions:
Gut Health
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Short chain fatty acids (mainly butyrate, acetate, and propionate) are produced in the large intestine by bacterial fermentation of undigested carbohydrates, such as dietary fibres. Butyrate is an imp...
Eligibility Criteria
Inclusion
- Clinical diagnosis of UC or Diarrhea predominant IBS
- Stable western diet
- Age between 18 and 65
- BMI between 18 and 35
- Written informed consent
Exclusion
- All enemas and suppository during or 2 weeks prior to the study
- Use of corticosteroids during or 1 month prior to the study
- Use of antibiotics during or 3 months prior to the study
- Budesonide during or 2 weeks prior to the study
- Changes in medication during or 1 month prior to the study
- Lactation, pregnancy and planning of pregnancy
- Previous intestinal surgery
- Clinically significant systemic diseases
- Excessive drinking (\>20 alcoholic consumptions per week)
- Changes in prebiotic and/or probiotic use during and 2 weeks prior to the study
- Previous radiotherapy or chemotherapy
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2009
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00696098
Start Date
May 1 2007
End Date
October 1 2009
Last Update
February 24 2017
Active Locations (1)
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1
University of Maastricht
Maastricht, Limburg, Netherlands, 6202 MD