Status:
COMPLETED
Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion
Lead Sponsor:
Hospital Centre Biel/Bienne
Collaborating Sponsors:
Brahms AG
Conditions:
Hypoosmolality
Hyperosmolality
Eligibility:
All Genders
18-80 years
Brief Summary
The are 2 principal goals in this study: 1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyper...
Eligibility Criteria
Inclusion
- chronic renal failure grade I through IV
- healthy age-matched controls
Exclusion
- chronic renal failure grade V
- heart failure
- liver disease
- nephrotic syndrome
- anemia (hemoglobin level \< 100 g/L)
- uncontrolled hypertension (systolic BP \> 160 mmHg; diastolic BP \> 95 mm Hg)
- coexisting severe disease
- known thyroid disease
- known hypocortisolism
- known hypercortisolism
- known diabetes insipidus
- pregnancy
- lactation
Key Trial Info
Start Date :
July 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2009
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00696605
Start Date
July 1 2008
End Date
October 1 2009
Last Update
February 27 2017
Active Locations (1)
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1
Clinic of Internal Medicine, Hospital Center
Biel/Bienne, Switzerland, 2501