Status:
UNKNOWN
The Effect of Sitagliptin on Hypertension, Arterial Stiffness, Oxidative Stress and Inflammation
Lead Sponsor:
Assaf-Harofeh Medical Center
Conditions:
Diabetes Mellitus
Arterial Stiffness
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin ...
Detailed Description
Background: Recently, a new category of hypoglycemic therapy has emerged, aimed to modulate the incretin system in diabetic patients. Compared to other drugs that induce insulin secretion, these agen...
Eligibility Criteria
Inclusion
- diabetic patients
- aged 18 years or older
- treated with metformin
- Only patients with HbA1C levels within the range 7% - 11% will be enrolled in the study
Exclusion
- CCT\<30
- A history of treatment with incretins or sulfonylurea during the last 3 months
- Treatment with nitrates
- Uncontrolled heart failure
- Uncontrolled hypertension and/or any change in the hypertensive medications within one month prior starting the study
- No proven regular treatment with aspirin or statins within one month prior starting the study
- Any malignancy with life expectancy of less then 1 year
- pregnancy
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2009
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00696982
Start Date
June 1 2008
End Date
June 1 2009
Last Update
June 13 2008
Active Locations (1)
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1
Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel
Zrifin, Israel, 70300