Status:
COMPLETED
ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls
Lead Sponsor:
University Hospital, Tours
Conditions:
Intrahepatic Cholestasis of Pregnancy
Eligibility:
FEMALE
18+ years
Brief Summary
Mutations of the ATP binding cassette subfamily B member 4 (ABCB4) gene, a gene involved in a subtype of progressive familial intrahepatic cholestasis, have been reported in women suffering from intra...
Detailed Description
Intrahepatic cholestasis of pregnancy was defined by pruritus and elevated serum alanine aminotransferase activity or bile acid concentration, with recovery after delivery. Patients with intercurrent ...
Eligibility Criteria
Inclusion
- For the control group :
- pregnant woman (age \> 18 years) during the third trimester
- caucasian and born in France
- multiparous (with at least 2 full term pregnancies)
- with informed written consent
Exclusion
- generalized pruritus and/or liver disease during pregnancy
- liver disease secondary to oral contraception
- Chronic liver disease
- disease during current pregnancy
Key Trial Info
Start Date :
July 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00700232
Start Date
July 1 2006
End Date
July 1 2009
Last Update
June 17 2010
Active Locations (1)
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1
Service de Gynécologie Obstétrique CHRU Tours
Tours, France, 37044