Status:
COMPLETED
Pravastatin and Ventilatory Associated Pneumonia
Lead Sponsor:
University of Thessaly
Conditions:
Ventilator Associated Pneumonia
Eligibility:
All Genders
14+ years
Phase:
EARLY_PHASE1
Brief Summary
Statins present anti-inflammatory and immunomodulatory effects. They may modify the regulation of cytokines, (released from the cellular damage) and may reduce the production of C-reactive protein lev...
Detailed Description
INTRODUCTION The pneumonia in the intensive care unit (I.C.U.) constitutes the most frequent infection and is most often associated with the application of the mechanical ventilation. VAP (Ventilator...
Eligibility Criteria
Inclusion
- Presence in Intensive Care Unit
Exclusion
- Pregnancy,
- Pneumonia, previous use of statins,
- Contraindications to statin use (liver dysfunction, SGOT/SGPT \> 100 U/L),
- Increased CPK (over 3 times the upper limit), (for non trauma patients) on admission,
- Increase of CPK (over 5 times the upper limit) during hospitalization,
- Use of substances that contraindicates simultaneous use of statins (macrolides, cyclosporine, antipyrin, cholestyramine, gemfibrosil, warfarin),
- Malabsorption syndrome (over the first 48 hours).
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT00702130
Start Date
June 1 2008
End Date
April 1 2010
Last Update
November 30 2011
Active Locations (2)
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1
General Hospital Larissa
Larissa, Thessaly, Greece, 41221
2
Zakynthinos E. Dir-University Hospital Larisa
Mezourlo / Larissa, Greece, 41110