Status:
COMPLETED
Progression Delaying Effect of Escitalopram in Alzheimer's Disease
Lead Sponsor:
Seoul National University Hospital
Collaborating Sponsors:
H. Lundbeck A/S
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
40-90 years
Phase:
NA
Brief Summary
This study aimed to test whether escitalopram would slow the brain atrophy in patients with mild to moderate AD over the 52-week period.
Detailed Description
* Study institutions: Four university hospitals in Korea * Design: Multi-center, randomized, placebo-controlled, double-blind clinical trial * Subjects: 74 probable Alzheimer's disease patients who ha...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age:40\~90 years
- Education:not illiterate
- Clinical Dementia Rating (CDR):0.5\~2
- Modified Hachinski Ischemic Score (Rosen et al., 1979):less than 4
- Dementia according to DSM-IV criteria
- Probable Alzheimer's disease according to NINCDS-ADRDA criteria
- Current ongoing donepezil medication at stable doses (5 \~ 10 mg/day) for at least 2 months
- Exclusion criteria:
- Evidence of delirium, confusion or altered consciousness
- Evidence of Parkinson's disease, stroke, brain tumor and normal pressure hydrocephalus
- Evidence of infectious or inflammatory brain disease
- Evidence of serious cerebrovascular diseases
- Current major depressive disorder or other major psychiatric illnesses
- Evidence of serious or unstable medical illnesses which can significantly change cognitive state
- History of alcohol or other substance dependence
- Any antidepressant medications within the previous 4 weeks
- Absence of a reliable and cooperative collateral informant
- Any conditions which prohibit MRI scan, such as presence of pacemaker or cerebrovascular clip, and claustrophobia
- Evidence of focal brain lesions on MRI including lacunes and white matter hyperintensity lesions of grade 2 or more by Fazeka scale
Exclusion
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT00702780
Start Date
November 1 2008
End Date
September 1 2011
Last Update
June 13 2014
Active Locations (4)
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1
Kangwon National University Hospital
Chuncheon, South Korea
2
Seoul National University Bundang Hospital
Seongnam, South Korea
3
Seoul National University Hospital
Seoul, South Korea, 110-744
4
Konkuk University Hospital
Seoul, South Korea