Status:
COMPLETED
Impact of Somatostatin Analogs vs. Surgery on Glucose Metabolism in Acromegaly
Lead Sponsor:
Federico II University
Conditions:
Acromegaly
Eligibility:
All Genders
18-80 years
Brief Summary
To investigate the 60 month impact of surgery and somatostatin analogues (SSA) on glucose metabolism in acromegaly we will analyzed data from 100 patients with acromegaly according with different trea...
Detailed Description
Impaired glucose tolerance (IGT) and overt diabetes mellitus are frequently associated with acromegaly. Patients with acromegaly are insulin resistant both in the liver and in the periphery, displayin...
Eligibility Criteria
Inclusion
- Patients treated with either first-line surgery via trans-sphenoidal route by microscopic and/or endoscopic approach or with first-line depot SSA treatment, or both and
- Patients with available follow-up after 60 months of treatment
Exclusion
- Patients requiring dopamine-agonists or pegvisomant
- Patients receiving the s.c. octreotide for longer than 15 days
- Patients receiving radiotherapy,
- Patients with a follow-up shorter than 60 months
Key Trial Info
Start Date :
January 1 1997
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00703079
Start Date
January 1 1997
End Date
June 1 2008
Last Update
June 23 2008
Active Locations (1)
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1
Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples
Naples, Italy, 80131