Status:
COMPLETED
Effect of Xalacom® (Latanoprost/Timolol) and Combigan® (Brimonidine/Timolol) Fixed Combination on Intraocular Pressure and Ocular Blood Flow in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
Lead Sponsor:
Medical University of Vienna
Conditions:
Retina
Ocular Physiology
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Glaucoma is one of the most common causes of blindness in the industrialized nations. For a long time glaucoma has been defined as a disease in which high intraocular pressure (IOP) leads to irreversi...
Eligibility Criteria
Inclusion
- Men and women over 18 years
- Unilateral or bilateral primary open angle glaucoma, ocular hypertension, exfoliation glaucoma, pigmentary glaucoma with IOP between 22 -35mmHg
- At least 3 reliable visual field testings
- 4 weeks for ß adrenergic receptor antagonists and prostaglandin analogues, 2 weeks for adrenergic agonists, and 5 days for cholinergic agonists and carbonic anhydrase inhibitors
Exclusion
- History of acute angle closure
- Closed or barely open anterior chamber angle
- Mean deviation of visual field testing \> 10
- Intraocular surgery or argon laser trabeculoplasty within the last six months
- Ocular inflammation or infection within the last three months
- Contact lenses
- Patients with bradycardia (heart rate \< 50 beats/min)
- Second and third degree heart block
- Asthma
- COPD
- Congestive heart failure
- Severe renal impairment (creatinine clearance \< 1.8 L/h)
- History of hypersensitivity to one of the study drugs or drugs with similar chemical structure
- Topical or systematically/oral therapy with steroids
- History of non-IOP responder to beta-blockers, alpha-2 adrenergic or prostaglandin analogues
- Pregnancy
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00706927
Start Date
January 1 2006
End Date
September 1 2010
Last Update
November 14 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Clinical Pharmacology
Vienna, Austria, 1090